What is the Rhynchophylline?

Rhynchophylline is Red brown or white fine powder, while it's Molecular Formula is C 22 H 28 N 2 O 4 . Red brown or white fine powder Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.

What is the CAS number for Rhynchophylline?

The CAS number of Rhynchophylline is 76-66-4.

What is Rhynchophylline (76-66-4) used for?

Rhynchophylline is an indole alkaloid glycoside identified as 6'-feruloylvinblastine lactam, isolated from *Uncaria rhynchophylla*, a plant used in traditional medicine. It was partially synthesized from vinblastine lactam, and its structure was characterized using spectroscopic methods. Rhynchophylline, along with other newly identified constituents, contributes to the plant's potential pharmacological properties.InChI:InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13-/t14-,15-,19?,22?/m0/s1

What is the Rhynchophylline?

Rhynchophylline is Red brown or white fine powder, while it's Molecular Formula is C 22 H 28 N 2 O 4 . Red brown or white fine powder Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.

What is the CAS number for Rhynchophylline?

The CAS number of Rhynchophylline is 76-66-4.

What is Rhynchophylline (76-66-4) used for?

Rhynchophylline is an indole alkaloid glycoside identified as 6'-feruloylvinblastine lactam, isolated from *Uncaria rhynchophylla*, a plant used in traditional medicine. It was partially synthesized from vinblastine lactam, and its structure was characterized using spectroscopic methods. Rhynchophylline, along with other newly identified constituents, contributes to the plant's potential pharmacological properties.InChI:InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13-/t14-,15-,19?,22?/m0/s1

Manufacturer supply high quality Rhynchophylline 76-66-4 with GMP standards

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Product

Rhynchophylline

CAS No.: 76-66-4
Purity: 99%

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Manufacturer supply high quality Rhynchophylline 76-66-4 with GMP standards

Molecular Formula: C₂₂H₂₈N₂O₄
Molecular Weight: 384.475
Appearance/Colour: Red brown or white fine powder
Vapor Pressure: 1.32E-12mmHg at 25°C
Melting Point: 216°; mp 197-199° (Ban et al., loc. cit.)
Refractive Index: 1.596
Boiling Point: 560.8 °C at 760 mmHg
PKA: 6.4(at 25℃)
Flash Point: 293 °C
PSA： 67.87000
Density: 1.23 g/cm³
LogP: 2.77610

Rhynchophylline(Cas 76-66-4) Usage

InChI:InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13-/t14-,15-,19?,22?/m0/s1

76-66-4 Relevant articles

Total synthesis of the spirocyclic oxindole alkaloids corynoxine, corynoxine B, corynoxeine, and rhynchophylline

Wanner, Martin J.,Ingemann, Steen,Van Maarseveen, Jan H.,Hiemstra, Henk

, p. 1100 - 1106 (2013/03/29)

Racemic total syntheses of four spirocyc...

Process for the production of specific isomer mixtures from oxindole alkaloids

-

, (2008/06/13)

To produce defined isomer mixtures of co...

76-66-4 Process route

: 630-94-4,51014-29-0
(±)-corynoxeine

: 76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7
rhynchophylline

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 18h; under 760.051 Torr;	97%

: C₂₅H₂₉N₃O₈S

: 76-66-4,6859-01-4,6877-32-3,17391-18-3,39032-61-6,39032-62-7
rhynchophylline

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: thiophenol; potassium carbonate / dimethyl sulfoxide / 2.15 h 2.1: triethylamine / acetonitrile / 2.33 h / 20 °C 3.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere 4.1: 6 h / 0 °C 5.1: tetrahydrofuran / 0.08 h / 20 °C 5.2: -78 - 20 °C 5.3: 20 h / 20 °C 6.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h / 760.05 Torr With bis(η3-allyl-μ-chloropalladium(II)); palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; acetonitrile; 5.2: \|Wittig Olefination;
Multi-step reaction with 6 steps 1.1: thiophenol; potassium carbonate / dimethyl sulfoxide / 2.15 h 2.1: triethylamine / acetonitrile / 2.33 h / 20 °C 3.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere 4.1: 6 h / 0 °C 5.1: tetrahydrofuran / 0.08 h / 20 °C 5.2: -78 - 20 °C 6.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h / 760.05 Torr With bis(η3-allyl-μ-chloropalladium(II)); palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; acetonitrile; 5.2: \|Wittig Olefination;

Yield

Multi-step reaction with 6 steps

1.1: thiophenol; potassium carbonate / dimethyl sulfoxide / 2.15 h

2.1: triethylamine / acetonitrile / 2.33 h / 20 °C

3.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere

4.1: 6 h / 0 °C

5.1: tetrahydrofuran / 0.08 h / 20 °C

5.2: -78 - 20 °C

5.3: 20 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h / 760.05 Torr

With bis(η3-allyl-μ-chloropalladium(II)); palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; acetonitrile; 5.2: |Wittig Olefination;