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Factory Supply industrial standard Ketanserin 74050-98-9 In Stock
- Molecular Formula:C22H22FN3O3
- Molecular Weight:395.433
- Melting Point:227-235 °C
- Refractive Index:1.592
- PKA:7.5(at 25℃)
- PSA：75.17000
- Density:1.281 g/cm3
- LogP:2.36170
Ketanserin(Cas 74050-98-9) Usage
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Purification Methods |
It has been purified by recrystallisation from 4-methyl-3-pentanone [Peeters et al. Cryst Structure Commun 11 375 1982, Kacprowicz et al. J Chromatogr 272 417 1983, Davies et al. J Chromatogr 275 232 1983]. It is an antihypertensive. |
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Definition |
ChEBI: A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group. |
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Brand name |
SEREFREX |
InChI:InChI=1/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
74050-98-9 Relevant articles
Ketoserin intermediate and preparation method of ketoserin
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Paragraph 0045-0046; 0059-0061, (2021/01/15)
The invention discloses a preparation me...
Reinvestigation of the synthesis of ketanserin (5) and its hydrochloride salt (5.HCl) via 3-(2-chloroethyl)-2,4-(1H,3H)-quinazolinedione (2) or dihydro-5H-oxazole(2,3-b)quinazolin-5-one (1)
Fakhraian, Hossein,Heydary, Mehdi
, p. 151 - 156 (2014/02/14)
The synthesis of ketanserin (5) and its ...
Floating pharmaceutical composition comprising an active phase and a non-active phase
-
, (2010/04/23)
The invention concerns a floating pharma...
Piperidinylalkyl quinazoline compounds, composition and method of use
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, (2008/06/13)
Novel quinazoline derivatives, comprisin...
74050-98-9 Process route
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56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone
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-
52727-44-3
2,3-dihydro-5H-oxazolo<2,3-b>quinazolin-5-one
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-
74050-98-9
ketanserine
| Conditions | Yield |
|---|---|
|
In
neat (no solvent);
at 110 ℃;
|
85% |
|
In
toluene;
for 40h;
Reflux;
|
80% |
-
-
25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride
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-
108-10-1
4-methyl-2-pentanone
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-
5081-87-8
3-(2-chloroethyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
-
-
74050-98-9
ketanserine
| Conditions | Yield |
|---|---|
|
With
sodium carbonate;
In
water;
|
2,2 parts (27%) |
74050-98-9 Upstream products
-
25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride
-
108-10-1
4-methyl-2-pentanone
-
5081-87-8
3-(2-chloroethyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
-
1207-75-6
2,4-Dioxo-3-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinazoline
74050-98-9 Downstream products
-
298696-31-8
2-[3-{2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl}-2,4-dioxo-3,4-dihydro-1(2H)-quinazolinyl]-N,N-dimethylacetamide hydrochloride
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76330-73-9
Ketanserinol
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83846-83-7
ketanserin tartrate
