Product
Chinese Factory Supply Wholesale Ethyl 2-forMylisonicotinate 21908-08-7 with Cheap Price
- Molecular Formula: C9H9NO3
- Molecular Weight: 179.175
- Boiling Point: 288.3±25.0 °C(Predicted)
- PKA: 1.20±0.10(Predicted)
- PSA： 56.26000
- Density: 1.204±0.06 g/cm3(Predicted)
- LogP: 1.07080
21908-08-7 Relevant articles
Selective DIBAL-H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo Lab
Uhlig, Nick,Martins, Andrew,Gao, Detian
, p. 2326 - 2335 (2020)
Herein we report a selective DIBAL-H-med...
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
Bavetsias, Vassilios,Lanigan, Rachel M.,Ruda, Gian Filippo,Atrash, Butrus,McLaughlin, Mark G.,Tumber, Anthony,Mok, N. Yi,Le Bihan, Yann-Va?,Dempster, Sally,Boxall, Katherine J.,Jeganathan, Fiona,Hatch, Stephanie B.,Savitsky, Pavel,Velupillai, Srikannathasan,Krojer, Tobias,England, Katherine S.,Sejberg, Jimmy,Thai, Ching,Donovan, Adam,Pal, Akos,Scozzafava, Giuseppe,Bennett, James M.,Kawamura, Akane,Johansson, Catrine,Szykowska, Aleksandra,Gileadi, Carina,Burgess-Brown, Nicola A.,Von Delft, Frank,Oppermann, Udo,Walters, Zoe,Shipley, Janet,Raynaud, Florence I.,Westaway, Susan M.,Prinjha, Rab K.,Fedorov, Oleg,Burke, Rosemary,Schofield, Christopher J.,Westwood, Isaac M.,Bountra, Chas,Müller, Susanne,Van Montfort, Rob L. M.,Brennan, Paul E.,Blagg, Julian
, p. 1388 - 1409 (2016)
We report the discovery of N-substituted...
HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF
-
Paragraph 00355; 00357, (2020/03/02)
Provided herein are compounds of Formula...
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
-
Paragraph 0090; 0093; 0094, (2016/09/22)
Provided are novel compounds of Formula ...
21908-08-7 Process route
-
-
41438-38-4
diethyl pyridine-2,4-dicarboxylate
-
-
21908-08-7
ethyl 2-formylpyridine-4-carboxylate
| Conditions | Yield |
|---|---|
|
diethyl pyridine-2,4-dicarboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at -78 ℃;
for 3h;
With
acetic acid;
In
tetrahydrofuran; water;
at 20 ℃;
for 1.5h;
|
81%
|
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; ethyl acetate; toluene;
at -40 ℃;
Temperature;
Solvent;
regioselective reaction;
Large scale;
|
67%
|
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 3.16667h;
regioselective reaction;
Inert atmosphere;
|
39%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -60 ℃;
for 1.33333h;
|
|
|
diethyl pyridine-2,4-dicarboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at -78 - 78 ℃;
for 3h;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
Cooling with ethanol-dry ice;
|
1.6 g
|
-
-
499-80-9
pyridine-2,4-dicarboxylic acid
-
-
21908-08-7
ethyl 2-formylpyridine-4-carboxylate
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: toluene-4-sulfonic acid / 16 h / 80 °C
2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 3.17 h / -78 °C / Inert atmosphere
With
diisobutylaluminium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; toluene;
|
|
|
Multi-step reaction
with
2
steps
1.1: sulfuric acid / Reflux
2.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 °C
2.2: 1.5 h / 20 °C
With
sulfuric acid; diisobutylaluminium hydride;
In
tetrahydrofuran;
|
|
|
Multi-step reaction
with
2
steps
1.1: sulfuric acid / ethanol / 14 h / 70 °C
2.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 - 78 °C
2.2: 1 h / 20 °C / Cooling with ethanol-dry ice
With
sulfuric acid; diisobutylaluminium hydride;
In
tetrahydrofuran; ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / Reflux
2: diisobutylaluminium hydride / ethyl acetate; tetrahydrofuran; toluene / -40 °C / Large scale
With
thionyl chloride; diisobutylaluminium hydride;
In
tetrahydrofuran; ethyl acetate; toluene;
|
21908-08-7 Upstream products
-
41438-38-4
diethyl pyridine-2,4-dicarboxylate
-
499-80-9
pyridine-2,4-dicarboxylic acid
21908-08-7 Downstream products
-
1596348-32-1
KDM5-C70
